Testosterone Replacement Therapy (TRT) Everything You Need To Know

Are you considering testosterone replacement therapy? For most people, their testosterone levels naturally decline between 0.4 to 2.6% per year as they age. Low testosterone affects between 4 and 5 million men in the USA alone. About 20 percent of men over 60 and 30 percent of men in their 70s and 80s have low testosterone. Women are also affected, but it’s more noticeable in men, whose testosterone levels are generally about twenty times higher than women’s. As a result, many men are seeking treatment to boost their testosterone levels, so they can feel and look like they did in their twenties and thirties. Some of these treatments include testosterone boosting supplements, prohormones, and testosterone replacement therapy which is the most commonly used form of treatment. If you think you are experiencing low testosterone levels, this article will teach you several things. So let’s get started!

The Symptoms of Low Testosterone

Although these are common symptoms of low testosterone, they are also related to many other medical disorders and disfunctions. Before seeking treatment, it’s important to undergo a blood test to get a more accurate diagnosis. The normal range of testosterone is roughly 300 to 1000ng/dL. Symptoms
  • Low sex drive
  • Erectile dysfunction
  • Low sperm count
  • Fatigue
  • Body and facial hair loss
  • Depression
  • Irritability
  • Hot flashes
  • Trouble building muscle
  • Increased body fat
  • Problems sleeping
  • Mood swings

Benefits of Testosterone Replacement Therapy

Taking testosterone boosting supplements enhance your body’s natural testosterone production. Research is still inconclusive about the long-term safety of testosterone replacement therapy. However, many scientists agree that the benefits outweigh the potential risks (4).  Here are some of those benefits.
  • Increases body density
  • Improves strength
  • Corrects of mild anemia
  • Improves mood
  • Increases sexual function
  • Improves erectile dysfunction (13, 14).
  • Improves bladder function (15).
  • Increases lean muscle mass
  • Decreases body fat
  • Reduce symptoms of depression (17, 18).

Risks of Testosterone Replacement Therapy

Although research is inconclusive on most of these risks, it’s good to be aware of their potential.
  • Risk of developing blood clots
  • Acne
  • Sleep apnea
  • Enlarge breasts
  • Testicle shrinking
  • Infertility
  • Potential prostate growth
  • Possible risk of heart disease
  • Exacerbate existing sleep apnea (22, 23).
Other research also suggests that men with late-onset low testosterone aren’t at risk for an enlarged prostate after TRT (19). In addition, although TRT hasn’t been linked to an increased risk of prostate cancer, but several studies have found a correlation between the two (20, 21).

Types of Testosterone Supplements and Treatments

There are several ways you can administer testosterone replacement therapy. Here are some of your options along with their pros and cons.

Oral Tablets

The most common way to take oral testosterone is by affixing a patch to the inside of your mouth. T undecanoate is the most preferred form of oral testosterone used by men (12). It’s available outside of the US under brand names likes Nibedo and Undestor. Pros:
  • No needles required.
  • Is not available in the United States (11).
  • Can cause liver toxicity (10).
  • Some men find it uncomfortable because it can dislodge while eating.
  • Can cause redness, pain, or swelling in the mouth.


Another common way people take testosterone is through injections. If you don’t mind needles, this one might be a good option. Pros:
  • lower maintenance than other treatments.
  • injections only need to be performed once every one to three weeks.
  • Dosages are easy to adjust since you don’t have to guess how much is being absorbed through your skin.
  • Regular use of needles
  • Can cause soreness where injection occurs
  • Can lead to a greater risk of cardiovascular complications, hospitalization, and death.

Topical Gels, Creams, and Patches

If oral treatments and injections don’t work for you, there’s always topic testosterone treatments. Here are the pros and cons. Pros:
  • No needles
  • Can administer at home without a doctor
  • Research published in JAMA found that gels and patches are safer than injections (9).
  • Doesn’t always absorb well through the skin
  • May not be as effective as injections
  • Have to make sure treated areas don’t come in contact with other people, especially women and children.
  • Have to administer daily in order to see desired effects.

TRT Reviews: People Who’ve Used Testosterone Replacement Therapy

Lots of people have tried testosterone replacement therapy. Their reviews have been pulled from Reddit and Youtube. Here are some of them: [su_highlight background=”#ffff99″]User #1: Visible Increase in muscle mass[/su_highlight] [su_highlight background=”#ffff99″]User #2: Didn’t see much change[/su_highlight] [su_highlight background=”#ffff99″]User #3: Increased strength and energy[/su_highlight] [su_highlight background=”#ffff99″]User #4: Improved sleep and lean muscle gain[/su_highlight] [su_highlight background=”#ffff99″]User #5: Dropped body fat, lean muscle gain, thicker hair[/su_highlight] [su_highlight background=”#ffff99″]User #6: Improved sexual performance[/su_highlight] [su_highlight background=”#ffff99″]One of the most well know guys who openly admits to using TRT is Joe Rogan:[/su_highlight]

Key Points to Consider with Testosterone Replacement Therapy

You’ve had a good overview of what testosterone replacement therapy is and the different options available for those suffering with low testosterone. Before deciding on a treatment option, here are some key things to remember
  • If you suspect you have low testosterone levels, get tested by your doctor before administering treatment.
  • Be aware that research is still inconclusive about the long-term health risks associated with doing Testosterone Replacement Therapy
  • Testosterone therapy can be expensive. According to an article in MensHealth, it can cost up to $10,000 per year (8).
  • Although TRT is a form of anabolic steroids, its dosages are much lower than those used by bodybuilders or athletes. It’s meant to raise testosterone to normal, healthy levels and not beyond.
  • Consider trying to increase your testosterone levels naturally first.
We wrote an article on how to increase your testosterone levels naturally here. (Have you tried testosterone replacement therapy? Feel free to share your story and results below! We would love to hear about it.)
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